A woman with a US size 10.5 foot would wear a Manolo Blahnik 41. If you are buying size 41 shoes, make sure to be careful with sedaraby's and mules. Those models are notorious for running a bit small and could possibly require a half size up (41.5). Most other models and types should fit true to size. Some may need a bit of spot stretching if there are some tight spots.
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